Drugs Delivery System
Nano-objects can be used for efficient delivery, and issues associated with premature drug degradation, unfavorable pharmacokinetics and systemic toxicity can be overcome by using a targeted drug delivery system (DDS) such as liposomes and other nanoparticles. The increased permeability of the inflamed tissue seen in different disease could lead to an accumulation of long circulating nanoparticles loaded with drugs by enhanced permeability and retention effect (EPR effect) at the location of inflammation. The macrophages locally present during the inflammatory phase will release the drug into the extracellular matrix. Macrophages can act as natural reservoirs of the drug slowly releasing it over time. This specific targeting will locally increase the drug concentration and improve the treatment.
The loading of drug is specific of the particles and the drug and need to be carefully study to obtain an efficient and reliable DDS.
Area of research related to DDS:
- Liposome encapsulation by microfluidic
- Polymerosome formulation
- Gene delivery
- Hydrogel systems
Block copolymer polymersome
Block copolymer micelles
Related papers
- Liew. MW.J, Wong YS, Parikh A.N., Venkatraman S, Cao Y and Czarny B.. (2023) Cell-mimicking polyethylene glycol-diacrylate based nanolipogel for encapsulation and delivery of hydrophilic biomolecule. Frontiers in Bioengineering and Biotechnology.
- Ravishankar S., Nedumaran A.M., Gautam A., Ng K.W., Czarny B., Sierin Lim S. (2023). Protein nanoparticle cellular fate and responses in murine macrophages. NPG Asia Materials,
- Lim PQ, Parikh A.N., Venkatraman S, and Czarny B.. (2023) Controlling the morphology of poly(ethylene glycol)-b-poly(lactide) (PEG-PLA) self-assemblies in solution: Interplay of homopolymer additive and kinetic traps, Research Square preprint
- SA Alkaff, K Radhakrishnan, AM Nedumaran, P Liao, B Czarny. Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies. International Journal of Nanomedicine. 2020
- Lim S.W.Z., Wong Y.S., Czarny B., and Venkatraman S.S. (2020). Microfluidic-directed self-assembly of liposomes: Role of interdigitation. Journal of Colloid and Interface Science, 578, 47-57.
- Darwitan A., Wong Y.S., Nguyen L.T.H., Czarny B., Vincent A., Nedumaran A.M., Tan Y.F., Muktabar A., Tang J.K., Ng K.W. and Venkatraman S.S. (2020). Liposomal Nanotherapy for Treatment of Atherosclerosis. Advanced Healthcare Materials, 9(14), 2000465
- Darwitan A., Tan Y.F., Wong Y.S., Nedumaran A.M., Czarny B., and Venkatraman S. (2020). Targeting efficiency of nanoliposomes on atherosclerotic foam cells: Polyethylene glycol-to-ligand ratio effects. Expert Opinion on Drug Delivery, 17(8), 1165-1176
- Wong YS, Czarny B, Venkatramana SS. Precision nanomedicine in atherosclerosis therapy: how far are we from reality? Precision Nanomedicine, 2019
- Wong CW*, Czarny B*, Metselaar J, Ho C, Ng SR, Veluchamy AB, Storm G, and Wong T Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis Scientific report, 2018
- Czarny BM, Allijn IE, Wang X, Chong SY, Weiler M, da Silva AE, Metselaar JM, Lam CS, Pastorin G, de Kleijn DP, Storm G, Wang JW, Schiffelers RM. Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction. J Control Release, 2017
